Metadata Architecture for Digital Libraries: Conceptual framework for Indian Digital Libraries

This paper describes approach of development of Metadata solution for digital library architecture for resource description and retrieval. This deals with the concept of Metadata [2], the different Metadata standards (Dublin core in particular [5]), Digital library environment, computer network capabilities etc. This paper also discusses two of the Digital Library architecture protocols, for resource description and retrieval. They are STARTS (Stanford Protocol Proposal for Internet Retrieval and Search) [8] and SODA (Smart Objects and Dump Archives)[13] architecture to arrive at a possible protocol that would help to build Indian Digital Libraries [5]. While proposing the new architecture the existing Indian environment with respect to information sources and user's query of the information sources [5.1], which are feasible for launch of this protocol for information processing and retrieval has been dealt with. This is a pilot study which the author has done while doing his Fulbright fellowship in the College of Library Information Studies, University of Maryland, College Park, MD during 1999-2000

Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery

Genes normally resident in euchromatic domains are silenced when packaged into heterochromatin, as exemplified in Drosophila melanogaster by position effect variegation (PEV). Loss-of-function mutations resulting in suppression of PEV have identified critical components of heterochromatin, including proteins HP1, HP2, and histone H3 lysine 9 methyltransferase. Here, we demonstrate that this silencing is dependent on the RNA interference machinery, using tandem mini-white arrays and white transgenes in heterochromatin to show loss of silencing as a result of mutations in piwi, aubergine, or spindle-E (homeless), which encode RNAi components. These mutations result in reduction of H3 Lys9 methylation and delocalization of HP1 and HP2, most dramatically in spindle-E mutants